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Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin


A 2017 article from the Journal of Investigative Dermatology (vol 37, p.1373) confirming the skin damage ozone causes through lipid peroxidation. The authors further observe that topically applied vitamin C appears effective in preventing these adverse effects on skin.

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It is generally shown that although [Ozone] is not a radical species per se, its toxic effects are mediated through free radical reactions, leading to lipid peroxidation [a form of skin damage].

Indeed, [Ozone] exposure is able to deplete antioxidant levels in the skin, and [antioxidant] topical application can prevent [Ozone]-induced skin damage. 

To our knowledge, this study with biopsy analysis is the first conducted in humans that is able to show that [Ozone] exposure can broadly affect cutaneous tissue. Topical application of vitamin C compound mixtures appears capable of preventing the observed effects

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