Methylparaben Potentiates UV-Induced Damage of Skin Keratinocytes

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An 2006 study summery from Toxicology (vol 227, nos 1-2, p.62) examining the effect of ultraviolet-B light ("UVB") on skin keratinocytes (also known as basal cells, they form a barrier against environmental damage). The authors found UVB exposure significantly increased skin damage through cell death, oxidative stress and lipid peroxidation among other causes.

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For many years, methylparaben (MP) has been used as a preservative in cosmetics. In this study, we investigated the effects of ultraviolet-B (UVB) exposure on MP-treated human skin keratinocytes.

UVB exposure significantly increased cell death, oxidative stress , NO production, lipid peroxidation and activation of transcription factors in MP-treated HaCaT keratinocytes. These results indicate that MP, which has been considered a safe preservative in cosmetics, may have harmful effects on human skin when exposed to ultraviolet-B.


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