Protective Effects of Astaxanthin on Skin Deterioration
Astaxanthin is a carotenoid with potent antioxidant and anti inflammatory activity. To evaluate the antiinflammatory effect of astaxanthin on skin deterioration, we confirmed its role in epidermaldermal interactions in vitro.
Clinical study of astaxanthin supplementation. A randomized, double-blind, parallel-group, placebo-controlled study was conducted to evaluate the effects of astaxanthin on wrinkle formation and other aspects of skin damage and aging.
Our findings indicated that astaxanthin inhibited inflammatory cytokine secretion from epidermal keratinocytes and MMP-1 secretion by dermal fibroblasts in response to UVB irradiation. These mechanisms underlie clinical study results that demonstrated that the suppression of seasonal deterioration of wrinkles and skin moisture and the improvements in skin elasticity were accompanied by sustaining low IL-1α levels in the epidermal corneum. Thus, long-term astaxanthin supplementation may prophylactically inhibit skin deterioration induced over time by environmental damage and consequently retard the skin aging process via its anti-inflammatory effect.