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Ozone-Exposure Depletes Vitamin E and Induces Lipid Peroxidation in Marine Stratum Corneum


A 1997 study from the Journal of Investigative Dermatology (vol 108, no 5, p.753) demonstrating the damaging effects of ozone to the outermost skin layer – the stratum corneum. The authors found that even small doses over time exert enough cumulative oxidative stress to stimulate free radical formation.

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The presence of ozone (O3) in photochemical smog an important health concern. We hypothesized that the stratum corneum (SC), as the outermost skin layer and the permeability barrier of the skin, represents a sensitive target for O3-induced oxidative stress.

We demonstrate that O3 depletes vitamin E in a dose-dependent fashion (0-10 ppm) and induces lipid peroxidation in the SC. Most notably, repeated exposures to the lowest tested O3 level (1 ppm) exerted cumulative oxidative stress effects.

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