Impact of Ozone Pollution on Main Repair Mechanisms (Autophagy & Circadian Rhythm)

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A 2018 study summary from Journal of Investigative Dermatology (vol 138, no 5, p.S237) measuring how ozone damage to skin lipids interrupts the one of the body’s internal cell regeneration processes – Autophagy.

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Ozone pollution at ground level is a growing worldwide environmental problem. Increased air pollution, UV exposure, and elevated temperatures all contribute to the formation of ozone (O3).

It has been proven that [ozone] creates oxidative damages on lipids from the epidermis but we also wanted to evaluate the impact on main repair mechanisms such as circadian rhythm and autophagy.

For the first time, we show that ozone pollution has a significant effect on level of per-1 and autophagy, decreasing both of them in skin cells. This impact at the core cellular machinery will result in a loss of repair and accumulation of damages in skin cells, which over time will accelerate aging.


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